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Publications Tim U. Krohne

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2020 Pape L, Ahlenstiel-Grunow T, Birtel J, Krohne TU, Hoppe B.
Oxalobacter formigenes treatment combined with intensive dialysis lowers plasma oxalate and halts disease progression in a patient with severe infantile oxalosis.
Pediatr Nephrol 2020 Jun;35(6):1121-1124.
Larsen PP, Oishi A, Bedar S, Heymer PK, Clemens CR, König S, Gutfleisch M, Pauleikhoff D, Eter N, Wolf A, Holz FG, Krohne TU.
Ranibizumab in pigment epithelial tears secondary to age-related macular degeneration: A prospective study.
Retina 2019 Dec;39(12):2369-2377.
  Wintergerst MWM, Petrak M, Li JQ, Larsen PP, Berger M, Holz FG, Finger RP, Krohne TU.
Non-contact smartphone-based fundus imaging compared to conventional fundus imaging: a low-cost alternative for retinopathy of prematurity screening and documentation.
Sci Rep 2019 Dec 23;9(1):19711.
[Pubmed] Open access: [Publisher PDF]
Larsen PP, Kipfmueller F, Holz FG, Reutter H, Müller A, Krohne TU.
Retinal findings in neonates with congenital diaphragmatic hernia and extracorporeal membrane oxygenation.
J Pediatr Surg 2019 Aug 25.
Wang L, Schmidt S, Larsen PP, Meyer JH, Roush WR, Latz E, Holz FG, Krohne TU.
Efficacy of novel selective NLRP3 inhibitors in human and murine retinal pigment epithelial cells.
J Mol Med 2019 Apr;97(4):523-532.
[Pubmed] Open access: [Publisher PDF]
Wang L, Petrak M, Holz FG, Müller A, Krohne TU.
Retinal hemorrhages in shaken baby syndrome.
J Pediatr 2019 Apr;207:256.
[Pubmed] Open access: [Publisher PDF]
Fang PP, Domdei N, Herrmann P, Schmitz-Valckenberg S, Holz FG, Harmening WM, Krohne TU.
Minimal optical coherence tomography B-scan density for reliable detection of intraretinal and subretinal fluid in macular diseases.
Retina 2019 Jan;39(1):150-156.
  Larsen PP, Thiele S, Krohne TU, Ziemssen F, Krummenauer F, Holz FG, Finger RP; OVIS-Study Group.
Visual impairment and blindness in institutionalized elderly in Germany.
Graefes Arch Clin Exp Ophthalmol 2019 Feb;257(2):363-370.
  Meyer JH, Larsen PP, Strack C, Harmening WM, Krohne TU, Holz FG, Schmitz-Valckenberg S.
Optical coherence tomography angiography (OCT-A) in an animal model of laser-induced choroidal neovascularization.
Exp Eye Res 2019 Jun;184:162-171.
  Bucher F, Friedlander MS, Aguilar E, Kurihara T, Krohne TU, Usui Y, Friedlander M.
The long dystrophin gene product Dp427 modulates retinal function and vascular morphology in response to age and retinal ischemia.
Neurochem Int 2019 Jun 11:104489.
Akhtar-Schäfer I, Wang L, Krohne TU, Xu H, Langmann T.
Modulation of three key innate immune pathways for the most common retinal degenerative diseases.
EMBO Mol Med 2018 Oct;10(10):e8259.
[Pubmed] Open access: [Publisher PDF]
Stahl A, Krohne TU, Eter N, Oberacher-Velten I, Guthoff R, Meltendorf S, Ehrt O, Aisenbrey S, Roider J, Gerding H, Jandeck C, Smith LEH, Walz JM; Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity (CARE-ROP) Study Group.
Comparing alternative ranibizumab dosages for safety and efficacy in retinopathy of prematurity: A randomized clinical trial.
JAMA Pediatr 2018 Mar 1;172(3):278-286.
[Pubmed] Open access: [Publisher PDF]
Krohne TU.
Retinopathy of prematurity: Current developments in therapy and epidemiology.
Ophthalmologe 2018 Jun;115(6):454-455.
[Pubmed] Open access: [Publisher PDF]
Krohne TU, Müller A, Larsen PP, Holz FG.
Long-term effects of anti-VEGF therapy for retinopathy of prematurity.
Ophthalmologe 2018 Jun;115(6):464-468.
[Pubmed] Open access: [Local PDF]
Larsen PP, Bründer MC, Petrak M, Jehle V, Lagrèze WA, Holz FG, Stahl A, Krohne TU.
Screening for retinopathy of prematurity: Trends over the past five years in two German university hospitals.
Ophthalmologe 2018 Jun;115(6):469-475.
[Pubmed] Open access: [Local PDF]
Walz JM, Bemme S, Reichl S, Akman S, Breuß H, Süsskind D, Glitz B, Müller VS, Wagenfeld L, Gabel-Pfisterer A, Aisenbrey S, Engelmann K, Koutsonas A, Krohne TU, Stahl A.
Treated cases of retinopathy of prematurity in Germany: 5-year data from the ROP registry.
Ophthalmologe 2018 Jun;115(6):476-488.
  Oishi A, Fang PP, Thiele S, Holz FG, Krohne TU.
Longitudinal change of outer nuclear layer after retinal pigment epithelial tear secondary to age-related macular degeneration.
Retina 2018 Jul;38(7):1331-1337.
Birtel J, Harmening WM, Krohne TU, Holz FG, Charbel Issa P, Herrmann P.
Retinal injury following laser pointer exposure.
Dtsch Arztebl Int 2017 Dec 8;114(49):831-837.
[Pubmed] Open access: [Publisher PDF]
Meyer JH, Fang PP, Krohne TU, Harmening WM, Holz FG, Schmitz-Valckenberg S.
Optical coherence tomography angiography (OCT-A) in rats.
Ophthalmologe 2017 Feb;114(2):140-147.
Feltgen N, Bertram B, Claessens D, Agostini H, Bartz-Schmidt U, Bornfeld N, Bresgen M, Hattenbach LO, Helbig H, Hoerauf H, Holz FG, Kirchhof B, Krohne TU, Lemmen KD, Pauleikhoff D, Roider J, Ziemssen F.
Leitlinie von Deutscher Ophthalmologischer Gesellschaft, Retinologischer Gesellschaft und Berufsverband der Augenärzte Deutschlands: Retinale arterielle Verschlüsse (RAV).
Ophthalmologe 2017 Feb;114(2):120-131.
Open access: [Local PDF]
Brandstetter C, Patt J, Holz FG, Krohne TU.
Inflammasome priming increases retinal pigment epithelial cell susceptibility to lipofuscin phototoxicity by changing the cell death mechanism from apoptosis to pyroptosis.
J Photochem Photobiol B 2016 May 21;161:177-183.
[Pubmed] Open access: [Author manuscript]
Krohne TU.
Medical myths in ophthalmology.
Ophthalmologe 2016 Dec;113(12):1009.
[Pubmed] Open access: [Publisher PDF]
Krohne TU, Allam JP, Novak N, Holz FG.
"Iodine allergy": A medical myth with risks for the ophthalmological patient.
Ophthalmologe 2016 Dec;113(12):1023-1028.
[Pubmed] Open access: [Local PDF]
  Lindner M, Fang PP, Steinberg JS, Domdei N, Pfau M, Krohne TU, Schmitz-Valckenberg S, Holz FG, Fleckenstein M.
OCT-angiography-based detection and quantification of the neovascular network in exudative AMD.
Invest Ophthalmol Vis Sci 2016 Nov 1;57(14):6342-6348.
Walz JM, Boehringer D, Deissler HL, Faerber L, Goepfert JC, Heiduschka P, Kleeberger SM, Klettner A, Krohne TU, Schneiderhan-Marra N, Ziemssen F, Stahl A.
Pre-analytical parameters affecting vascular endothelial growth factor measurement in plasma: Identifying confounders.
PLoS One 2016 Jan 5;11(1):e0145375.
[Pubmed] Open access: [Publisher PDF]
Walz JM, Bemme S, Pielen A, Aisenbrey S, Breuß H, Alex AF, Wagenfeld L, Schiedel S, Krohne TU, Stahl A, ROP Registry.
The German ROP Registry: data from 90 infants treated for retinopathy of prematurity.
Acta Ophthalmol 2016 Dec;94(8):e744-e752.
  Krohne TU, Holz FG, Meyer CH.
Pharmacokinetics of intravitreally applied VEGF inhibitors.
In: Stahl A (ed.), Anti-Angiogenic Therapy in Ophthalmology, 1st ed., pp. 139-148. Springer, Berlin, 2016.
Holz FG, Krohne TU.
New perspectives in retinal imaging with OCT angiography.
Ophthalmologe 2016 Jan;113(1):4-5.
Fang PP, Harmening WM, Müller PL, Lindner M, Krohne TU, Holz FG.
Technical principles of OCT angiography.
Ophthalmologe 2016 Jan;113(1):6-13.
Fang PP, Lindner M, Steinberg JS, Müller PL, Gliem M, Charbel Issa P, Krohne TU, Holz FG.
Clinical applications of OCT angiography.

Ophthalmologe 2016 Jan;113(1):14-22.
  Meyer CH, Krohne TU, Charbel Issa P, Liu Z, Holz FG.
Routes for drug delivery to the eye and retina: Intravitreal injections.
Dev Ophthalmol 2016;55:63-70.
Brandstetter C, Holz FG, Krohne TU.
Complement component C5a primes retinal pigment epithelial cells for inflammasome activation by lipofuscin-mediated photooxidative damage.
J Biol Chem 2015 Dec 25;290(52):31189-98.
[Pubmed] Open access: [Publisher PDF]
  Mohr LKM, Hoffmann AV, Brandstetter C, Holz FG, Krohne TU.
Effects of inflammasome activation on secretion of inflammatory cytokines and vascular endothelial growth factor by retinal pigment epithelial cells.
Invest Ophthalmol Vis Sci 2015 Oct 1;56(11):6404-13.
[Pubmed] Open access: [Publisher PDF]
  Brandstetter C, Mohr LKM, Latz E, Holz FG, Krohne TU.
Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage.
J Mol Med 2015 Aug;93(8):905-16.
[Pubmed] Open access: [Publisher PDF]
  Krohne TU, Muether PS, Stratmann NK, Holz FG, Kirchhof B, Meyer CH, Fauser S.
Influence of ocular volume and lens status on pharmacokinetics and duration of action of intravitreal vascular endothelial growth factor inhibitors.
Retina 2015 Jan;35(1):69-74.
  Krohne TU, Gerste RD.
Künstliche Netzhaut aus Stammzellen.
Z Prakt Augenheilkd 2015 Feb;36(2):51-3.
Open access: [Local PDF]
2014 Krohne TU, Holz FG, Meyer CH.
Pharmacokinetics of intravitreally administered VEGF inhibitors.
Ophthalmologe 2014 Feb;111(2):113-20.
[Pubmed] Open access: [Local PDF]
  Meyer CH, Krohne TU.
Ocular pharmacokinetics: Topical, intravitreal, and systemic drug application.
Ophthalmologe 2014 Feb;111(2):104-6.
[Pubmed] Open access: [Publisher PDF]
2013 Krohne TU.
Perspectives of stem cell therapy.
Ophthalmologische Nachrichten 2013 Sep:11.
Open access: [Local PDF]
  Hoerauf H, Holz FG, Kramer A, Feltgen N, Krohne TU, Behrens-Baumann W.
Stellungnahme der Deutschen Ophthalmologischen Gesellschaft, der Retinologischen Gesellschaft und des Berufsverbandes der Augenärzte Deutschlands zur Endophthalmitis-Prophylaxe bei intravitrealer operativer Medikamenteneingabe (IVOM).
Ophthalmologe 2013 Oct;110(10):1008-12.
[Pubmed] Open access: [Local PDF]
  Hoerauf H, Holz FG, Kramer A, Feltgen N, Krohne TU, Behrens-Baumann W.
Statement of the German Ophthalmological Society, the Retina Society and the Professional Association of German Ophthalmologists: endophthalmitis prophylaxis intravitreal operative medications input (IVOM) (July 2013).
Klin Monbl Augenheilkd 2013 Nov;230(11):1157-61.
  Aretz S, Krohne TU, Kammerer K, Warnken U, Hotz-Wagenblatt A, Bergmann M, Stanzel BV, Kempf T, Holz FG, Schnölzer M, Kopitz J.
In-depth mass spectrometric mapping of the human vitreous proteome.
Proteome Sci 2013 May 20;11(1):22.
[Pubmed] Open access: [Publisher PDF]
2012 Krohne TU, Westenskow PD, Kurihara T, Friedlander DF, Lehmann M, Dorsey AL, Li W, Zhu S, Schultz A, Wang J, Siuzdak G, Ding S, Friedlander M.
Generation of retinal pigment epithelial cells from small molecules and OCT4 reprogrammed human induced pluripotent stem cells.
Stem Cells Trans Med 2012 Feb;1(2):96-109.
[Pubmed] Open access: [Publisher PDF]
  Krohne TU.
Retinopathy of prematurity: Current aspects of pathogenesis, diagnostics and therapy.
Ophthalmologe 2012 Dec;109(12):1173.
[Pubmed] Open access: [Local PDF]
  Krohne TU, Aisenbrey S, Holz FG.
Current therapeutic options in retinopathy of prematurity.
Ophthalmologe 2012 Dec;109(12):1189-97.
[Pubmed] Open access: [Local PDF]
  Stahl A, Krohne TU, Limburg E.
Register zur Erfassung behandlungsbedürftiger Frühgeborenenretinopathie.
Z prakt Augenheilkd 2012;33:500-4.
  Stahl A, Aisenbrey S, Krohne TU.
Retinopathy of prematurity - Pathophysiologic mechanisms and new treatment options.
Klin Monbl Augenheilkd 2012 Oct;229(10):1024-9.
  Krohne TU, Liu Z, Holz FG, Meyer CH.
Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans.
Am J Ophthalmol 2012 Oct;154(4):682-686.
[Pubmed] Open access: [Author manuscript]
  Westenskow PD, Moreno SK, Krohne TU, Kurihara T, Zhu S, Zhang Z, Zhao T, Xu Y, Ding S, Friedlander M.
Using flow cytometry to compare the dynamics of photoreceptor outer segment phagocytosis in iPS derived RPE cells.
Invest Ophthalmol Vis Sci 2012 Sep 14;53(10):6282-90.
[Pubmed] Open access: [Publisher PDF]
  Clemens CR, Krohne TU (shared first author), Charbel Issa P, Helb HM, Kosanetzky N, Lommatzsch A, Holz FG, Eter N.
High-resolution optical coherence tomography of subpigment epithelial structures in patients with pigment epithelium detachment secondary to age-related macular degeneration.
Br J Ophthalmol 2012 Aug;96(8):1088-91.
  Meyer CH, Krohne TU (shared first author), Holz FG.
Concentrations of unbound bevacizumab in the aqueous of untreated fellow eyes after a single intravitreal injection in humans.
Acta Ophthalmol 2012 Feb;90(1):68-70.
[Pubmed] Open access: [Publisher PDF]
  Krohne TU, Stahl A, Aisenbrey S, Bertram B, Gerding H, Helbig H, Jandeck C, Kellner U, Lagreze WA, Lorenz B, Muether PS, Roider J, Seiberth V.
Stellungnahme der Deutschen Ophthalmologischen Gesellschaft, der Retinologischen Gesellschaft und des Berufsverbandes der Augenärzte Deutschlands zum Einsatz von Bevacizumab in der Therapie der Frühgeborenenretinopathie.
Ophthalmologe 2012 Feb;109(2):197-204.
[Pubmed] Open access: [Local PDF]
2011 Kurihara T, Westenskow PD, Krohne TU, Aguilar E, Johnson RS, Friedlander M.
Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye.
J Cell Biol 2011 Nov 14;195(4):689-701.
[Pubmed] Open access: [Internet]
  Stahl A, Krohne TU, Sapieha P, Chen J, Hellstrom A, Chew E, Holz FG, Smith LEH.
Lipid metabolites in pathogenesis and treatment of neovascular eye disease.
Br J Ophthalmol 2011 Nov;95(11):1496-501. (Review)
[Pubmed] Open access: [Internet]
  Krohne TU.
Stem cell therapy in retinal diseases - Current preclinical research results and upcoming clinical trials.
Retinal Physician 2011 May:26-29. (Review)
Open access: [Internet]
  Meyer CH, Krohne TU, Holz FG.
Intraocular pharmacokinetics after a single intravitreal injection of 1.5 mg versus 3.0 mg of bevacizumab in humans.
Retina 2011 Oct;31(9):1877-84.
  Stahl A, Krohne TU.
Anti-VEGF bei Frühgeborenenretinopathie - Pathomechanistische Grundlagen und kritische Evaluation der klinischen Daten.
Ophthalmologische Nachrichten 2011 Aug:9. (Review)
Open access: [PDF]
2010 Weidemann A, Krohne TU (shared first author), Aguilar E, Kurihara T, Takeda N, Dorrell MI, Simon MC, Haase VH, Friedlander M, Johnson RS.
Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina.
Glia 2010 Aug;58(10):1177-85.
[Pubmed] Open access: [Author manuscript]
  Krohne TU, Holz FG, Kopitz J.
Apical-to-basolateral transcytosis of photoreceptor outer segments induced by lipid peroxidation products in human retinal pigment epithelial cells.
Invest Ophthalmol Vis Sci 2010 Jan;51(1):553-60.
[Pubmed] Open access: [Internet]
  Krohne TU, Kaemmerer E, Holz FG, Kopitz J.
Lipid peroxidation products reduce lysosomal protease activities in human retinal pigment epithelial cells via two different mechanisms of action.
Exp Eye Res 2010 Feb;90(2):261-6.
[Pubmed] Open access: [Author manuscript]
  Krohne TU, Stratmann NK, Kopitz J, Holz FG.
Effects of lipid peroxidation products on lipofuscinogenesis and autophagy in human retinal pigment epithelial cells.
Exp Eye Res 2010 Mar;90(3):465-71.
[Pubmed] Open access: [Author manuscript]
  Krohne TU, Herrmann P, Kopitz J, Rüther K, Holz FG.
Juvenile neuronal ceroid lipofuscinosis. Ophthalmologic findings and differential diagnosis
Ophthalmologe 2010 Jul;107(7):606-11. (Review)
[Pubmed] Open access: [PDF]
  Marchetti V, Krohne TU, Friedlander DF, Friedlander M.
Stemming vision loss with stem cells.
J Clin Invest 2010 Sep 1;120(9):3012-21. (Review)
[Pubmed] Open access: [PDF]
  Krohne TU, Bird AC, Friedlander M.
Unilateral blurred vision associated with combined macular and papillary edema: A 34-year-old male patient.
Ophthalmologe 2010 Dec;107(12):1160-1163. (Case report)
[Pubmed] Open access: [PDF]
  Finger RP, Krohne TU, Charbel Issa P, Scholl HP, Holz FG.
No evidence to support the use of plasmapheresis for age-related macular degeneration.
Ther Apher Dial 2010 Dec;14(6):607-8. (Comment)
2009 Krohne TU, Hunt S, Holz FG.
Effect of 308nm excimer laser irradiation on RPE cell viability in vitro.
Br J Ophthalmol 2009 Jan;93(1):91-5.
  Finger RP, Krohne TU, Charbel Issa P, Fleckenstein M, Scholl HP, Holz FG.
Plasmapheresis for dry age-related macular degeneration--evidence based?
Retina 2009 May;29(5):569-72. (Editorial)
  Kociok N, Radetzky S, Krohne TU, Gavranic C, Liang Y, Semkova I, Joussen AM.
ICAM-1 depletion does not alter retinal vascular development in a model of oxygen-mediated neovascularization.
Exp Eye Res 2009 Oct;89(4):503-10.
  Joussen AM, Doehmen S, Le ML, Koizumi K, Radetzky S, Krohne TU, Poulaki V, Semkova I, Kociok N.
TNF-alpha mediated apoptosis plays an important role in the development of early diabetic retinopathy and long-term histopathological alterations.
Mol Vis 2009 Jul 25;15:1418-28.
[Pubmed] Open access: [Internet]
2008 Krohne TU, Eter N, Holz FG, Meyer CH.
Intraocular Pharmacokinetics of Bevacizumab After a Single Intravitreal Injection in Humans.
Am J Ophthalmol 2008 Oct;146(4):508-512.
[Pubmed] Open access: [Author manuscript]
2007 Kaemmerer E, Schutt F, Krohne TU, Holz FG, Kopitz J.
Effects of lipid peroxidation-related protein modifications on RPE lysosomal functions and POS phagocytosis.
Invest Ophthalmol Vis Sci 2007 Mar;48(3):1342-7.
[Pubmed] Open access: [Internet]
  Kociok N, Krohne TU, Poulaki V, Joussen AM.
Geldanamycin treatment reduces neovascularization in a mouse model of retinopathy of prematurity.
Graefes Arch Clin Exp Ophthalmol 2007 Feb;245(2):258-66.
2006 Eter N, Krohne TU, Holz FG.
New pharmacologic approaches to therapy for age-related macular degeneration.
BioDrugs 2006;20(3):167-79. (Review)
  Kociok N, Radetzky S, Krohne TU, Gavranic C, Joussen AM.
Pathological but not physiological retinal neovascularization is altered in TNF-Rp55-receptor-deficient mice.
Invest Ophthalmol Vis Sci 2006 Nov;47(11):5057-65.
[Pubmed] Open access: [Internet]
2005 Krohne TU, Inhetvin-Hutter C, Holz FG.
Unilateral visual loss in the presence of retinal haemorrhages in a 35-year old woman.
Ophthalmologe 2005 Jun;102(6):622-4. (Case report)
[Pubmed] Open access: [PDF]
  Scholl HP, Fleckenstein M, Krohne TU, Holz FG
Classification of biomedical research reports as a reference for evidence-based medicine in ophthalmology. A survey considering as example the journal Der Ophthalmologe.
Ophthalmologe 2005 Dec;102(12):1152-61.
[Pubmed] Open access: [PDF]
2004 Fauser S, Kalbacher H, Alteheld N, Koizumi K, Krohne TU, Joussen AM.
Pharmacokinetics and safety of intravitreally delivered etanercept.
Graefes Arch Clin Exp Ophthalmol 2004 Jul;242(7):582-6.
2003 Krohne TU, Fauser S, Kirchhof B, Joussen AM.
Pathogenesis of diabetic macular oedema.
Klin Monbl Augenheilkd 2003 Aug;220(8):521-5. (Review)
  Fauser S, Krohne TU, Kirchhof B, Joussen AM.
Diabetic maculopathy - classification and therapy.
Klin Monbl Augenheilkd 2003 Aug;220(8):526-31. (Review)
  Joussen AM, Fauser S, Krohne TU, Lemmen KD, Lang GE, Kirchhof B.
Diabetic retinopathy. Pathophysiology and therapy of hypoxia-induced inflammation.
Ophthalmologe 2003 May;100(5):363-70. (Review)
[Pubmed] Open access: [PDF]
  Fauser S, Engelmann K, Krohne TU, Lappas A, Kirchhof B, Joussen AM.
Pathogenesis of choroidal neovascularization. Old concepts, new questions.
Ophthalmologe 2003 Apr;100(4):300-5. (Review)
[Pubmed] Open access: [PDF]
2001 Krohne TU, Shankara S, Geissler M, Roberts B, Wands JR, Blum HE, Mohr L.
Mechanisms of cell death induced by suicide genes encoding purine nucleoside phosphorylase and thymidine kinase in human hepatocellular carcinoma cells in vitro.
Hepatology 2001 Sep;34(3):511-18.
[Pubmed] Open access: [Internet]
  Kroger A, Ortmann D, Krohne TU, Mohr L, Blum HE, Hauser H, Geissler M.
Growth suppression of the hepatocellular carcinoma cell line Hepa1-6 by an activatable interferon regulatory factor-1 in mice.
Cancer Res 2001 Mar 15;61(6):2609-17.
[Pubmed] Open access: [Internet]
  Geissler M, Mohr L, Weth R, Kohler G, Grimm CF, Krohne TU, Von Weizsacker F, Blum HE.
Immunotherapy directed against alpha-fetoprotein results in autoimmune liver disease during liver regeneration in mice.
Gastroenterology 2001 Oct;121(4):931-9.
[Pubmed] Open access: [Internet]
2000 Mohr L, Shankara S, Yoon SK, Krohne TU, Geissler M, Roberts B, Blum HE, Wands JR.
Gene therapy of hepatocellular carcinoma in vitro and in vivo in nude mice by adenoviral transfer of the Escherichia coli purine nucleoside phosphorylase gene.
Hepatology 2000 Mar;31(3):606-14.
[Pubmed] Open access: [Internet]
  Grimm CF, Ortmann D, Mohr L, Michalak S, Krohne TU, Meckel S, Eisele S, Encke J, Blum HE, Geissler M.
Mouse alpha-fetoprotein-specific DNA-based immunotherapy of hepatocellular carcinoma leads to tumor regression in mice.
Gastroenterology 2000 Oct;119(4):1104-12.
[Pubmed] Open access: [Internet]