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Retinal Cell Biology Group (T. Krohne)





Research areas

Pathogenesis of age-related macular degeneration

  • NLRP3 inflammasome activation induced by lipofuscin-mediated photooxidative damage in AMD (DFG grant KR 2863/7-2)
  • Preclinical evaluation of selective small-molecule NLRP3 inhibitors as novel therapeutic strategy in atrophic AMD
  • Intraocular profiling of inflammatory cytokines in patients with intermediate and atrophic AMD
  • Assessment of increased reactivity of innate immune system signalling pathways in AMD patients
  • Completed: Lipid peroxidation and RPE lysosomal dysfunction
    Oxidatively damaged POS induce lysosomal dysfunction in RPE cells.

Stem cells in retinal diseases

  • In vitro modelling of retinal neurodegenerative diseases using patient-derived induced pluripotent stem cells (iPS cells) 

Ocular Pharmacokinetics