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Effect of intraocular excimer laser application on RPE cell DNA integrity and cell viability

Dr. med. Tim U. Krohne
Claudine Strack, BTA
Dr. rer. nat. Suzan Hunt
Prof. Dr. med. Frank G. Holz

 

Summary

Transplantation of an autologous RPE sheet under the macula is a new option for surgical treatment of age-related macular degeneration (AMD). Intraocular 308nm excimer laser is used for microablation of choroidal tissue of the RPE sheet to improve graft implantation as well as diffusion of metabolites to and from the retina (figure).

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In this project we examine potential adverse effects of choroidal microablation on the graft RPE cell layer. We focus on DNA damage and cytotoxicity induced by radiation, thermal and mechanical aspects of the excimer laser pulse.

 

References

Krohne TU, Hunt S, Holz FG.
Effect of 308nm excimer laser irradiation on RPE cell viability in vitro.
Br J Ophthalmol. 2009 Jan;93(1):91-5. [PubMed abstract]

Bindewald A, Roth F, Van Meurs J, Holz FG.
Transplantation of retinal pigment pithelium (RPE) following CNV removal in patients with AMD. Techniques, results, outlook.
Ophthalmologe. 2004 Sep;101(9):886-94. [PubMed abstract]

Holz FG, Bindewald A, Schutt F, Specht H.
Intraocular microablation of choroidal tissue by a 308 nm AIDA excimer laser for RPE-transplantation in patients with age-related macular degeneration.
Biomed Tech (Berl). 2003 Apr;48(4):82-5. [PubMed abstract]

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