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Morphology of spontaneous ocular anomalies occurring in ageing APO E mice

Sabine Günther
Dipl.-Biol. Elvira Allahyarova
Priv.-Doz. Dr. rer. nat. Alfred Wegener

 

Summary

The APO E mouse is a genetically engineered model for apo-lipoprotein E deficiency, causing obesity and blood vessel wall calcifications. The animals have a high frequency of stroke and are very stress sensitive. The occurrence of spontaneous ocular anomalies has been monitored over 1 year and every 3 months whole eyes have been sampled and processed for histology. Band-shaped keratopathies as well as anterior and posterior subcapsular cataracts have been found in high frequencies. The data point to a hitherto unknown effect of APO E deficiency on epithelial growth control.

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